2010 Fiscal Year Final Research Report
Development of hypoglycemic drugs using diabetic silkworm model
| Project/Area Number |
21790062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUMOTO Yasuhiko The University of Tokyo, 大学院・薬学系研究科, 助教 (60508141)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖尿病 / 血糖降下薬 / カイコ / 無脊椎動物モデル |
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| Research Abstract |
We have proposed a novel method for development of drugs using invertebrate pathogenic animal model. In this study, we established hyperglycemic model in silkworm and identified galactose as a hypoglycemic drug from herbal medicine, jiou, by monitoring hypoglycemic activity in the hyperglycemic silkworm model. Moreover, we also developed diabetic complication model in silkworm. This is a first report to identify anti-diabetic compound using invertebrate hypoglycemic model.
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Research Products
(8 results)
