2010 Fiscal Year Final Research Report
Molecular mechanism of apoptotic pathway through the tumor suppressor protein p53 approached from gene expression control
| Project/Area Number |
21790066
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
TANAKA Aki University of Toyama, 医学薬学研究部(薬学), 助教 (50432109)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 転写 |
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| Research Abstract |
The general transcription factors TFIIE and TFIIH play essential roles in transcription initiation by RNA polymerase II. The possibility is shown that the phosphorylation modification of tumor suppressor protein p53 at serin 46 and threonine 55 influence the interaction of two factors. It is shown that p53 received DNA damage by ultraviolet and anti-cancer drug stabilized in the cell, the interaction with TFIIH is given to priority more than interactive with TFIIE by the post-translational modification of p53.
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