2010 Fiscal Year Final Research Report
Elucidation of regulatory mechanisms for cancer cell proliferation and malignancies by microRNA in esophageal squamous cell carcinoma
| Project/Area Number |
21790072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUCHIYA Soken Kyoto University, 薬学研究科, 助教 (80423002)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞増殖制御メカニズム |
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| Research Abstract |
Here, we reports that the expression of microRNA-210 (miR-210) is downregulated in human esophageal squamous cell carcinoma (ESCC) and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. We found that miR-210 inhibits cancer cell survival and proliferation by inducing cell death and cell cycle arrest in G1/G0 and G2/M. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target of miR-210 in ESCC, and demonstrated that FGFRL1 accelerates cancer cell proliferation by preventing cell cycle arrest in G1/G0. Taken together, our findings show an important role for miR-210 as a tumor suppressive microRNA with effects on cancer cell proliferation.
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