2010 Fiscal Year Final Research Report
The roles of Fgf signaling in development of neurons.
| Project/Area Number |
21790075
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
MIYAKE Ayumi Kyoto University, 薬学研究科, 講師 (40346044)
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| Project Period (FY) |
2009 – 2010
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| Keywords | FGF / ゼブラフィッシュ / 脳・神経形成 / GABA作動性ニューロン |
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| Research Abstract |
The specification of GABAergic interneurons and oligodendrocytes by Fgf19 signaling may be mediated through Fgfr1- and Fgfr4-MAPK pathways. It is suggested that Fgf16 and Fgf22 are also involved in the specification of GABAergic interneurons and oligodendrocytes generated in the ventral telencephalon and diencephalon. Furthermore, Fgf22 is involved in cell proliferation and cell survival during embryonic brain development. Fgf22 is also essential for development of the ventral telencephalon and diencephalon.
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[Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family.2009
Author(s)
A.Miyake, H.Miwa, Y.Kouta, A.Shimada, Y.Yamashita, Y.Nakayama, H.Yamauchi, M.Konishi, N.Itoh.
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Journal Title
FEBS Lett. 583
Pages: 3643-3648
Peer Reviewed
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