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2010 Fiscal Year Final Research Report

The roles of Fgf signaling in development of neurons.

Research Project

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Project/Area Number 21790075
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

MIYAKE Ayumi  Kyoto University, 薬学研究科, 講師 (40346044)

Project Period (FY) 2009 – 2010
KeywordsFGF / ゼブラフィッシュ / 脳・神経形成 / GABA作動性ニューロン
Research Abstract

The specification of GABAergic interneurons and oligodendrocytes by Fgf19 signaling may be mediated through Fgfr1- and Fgfr4-MAPK pathways. It is suggested that Fgf16 and Fgf22 are also involved in the specification of GABAergic interneurons and oligodendrocytes generated in the ventral telencephalon and diencephalon. Furthermore, Fgf22 is involved in cell proliferation and cell survival during embryonic brain development. Fgf22 is also essential for development of the ventral telencephalon and diencephalon.

  • Research Products

    (7 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] The FGF Family in Humans, Mice, and Zebrafish : Development,Physiology, and Pathophysiology2011

    • Author(s)
      S.Sasaki, Y.Nakayama, M.Konishi, A.Miyake, N.Itoh.
    • Journal Title

      Genetic Disease (in press)

    • Peer Reviewed
  • [Journal Article] A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family.2009

    • Author(s)
      A.Miyake, H.Miwa, Y.Kouta, A.Shimada, Y.Yamashita, Y.Nakayama, H.Yamauchi, M.Konishi, N.Itoh.
    • Journal Title

      FEBS Lett. 583

      Pages: 3643-3648

    • Peer Reviewed
  • [Journal Article] Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling.2009

    • Author(s)
      A.Miyake, Y.Takahashi, H.Miwa, A.Shimada, M.Konishi, N.Itoh.
    • Journal Title

      Biochem. Biophys. Res.Commun. 390

      Pages: 1051-1055

    • Peer Reviewed
  • [Journal Article] Fgf4 is required for left-right patterning of visceral organs in zebrafish.2009

    • Author(s)
      H.Yamauchi, N.Miyakawa, A.Miyake, N.Itoh.
    • Journal Title

      Dev.Biol. 332

      Pages: 177-185

    • Peer Reviewed
  • [Presentation] 脳形成におけるzebrafish neucrinの機能解析2010

    • Author(s)
      三宅歩、新野智香、伊藤信行
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-07
  • [Presentation] 網膜形成における新規分泌性タンパク質の機能解析2009

    • Author(s)
      新野智香、三宅歩、伊藤信行
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-12
  • [Remarks] ホームページ等

    • URL

      http://www.pharm.kyoto-u.ac.jp/idenshi/

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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