Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790077
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Osaka University
• Principal Investigator: SHINTANI Norihito Osaka University, 大学院・薬学研究科, 准教授 (10335367)
• Project Period (FY): 2009 – 2010
• Keywords: 薬理学 / プロスタグランジン / 遺伝子欠損マウス

Research Abstract

In this study, I aimed to determine the central function of CRTH2 by using agonists, antagonists, and knockout mice of CRTH2. I found that CRTH2 is involved in light-induced phase advance of circadian rhythm, lipopolysaccharide (LPS)-induced decrease of novel-object exploration behavior, and 15-deoxy-PGJ2 enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. These results demonstrate for the first time the role of CRTH2 in higher brain function.

Research Products

• [Journal Article] 15d-prostaglandin J_2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. (2010)
  • Author(s): Hatanaka M, Shibata N, Shintani N, Haba R, Hayata A, Hashimoto H, Baba A.
  • Journal Title: J Pharmacol Sci. 113(1) Pages: 89-93
  • Peer Reviewed
• [Journal Article] PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset. (2010)
  • Author(s): Kawaguchi C, Isojima Y, Shintani N, Hatanaka M, Guo X, Okumura N, Nagai K, Hashimoto H, Baba A.
  • Journal Title: PLoS One 5(2) Pages: e9286
  • Peer Reviewed
• [Journal Article] Regulation of autonomic nerve activities by central pituitary adenylate cyclase-activating polypeptide. (2010)
  • Author(s): Tanida M, Shintani N, Morita Y, Tsukiyama N, Hatanaka M, Hashimoto H, Sawai H, Baba A, Nagai K.
  • Journal Title: Regul Pept. 161(1-3) Pages: 73-80
  • Peer Reviewed
• [Presentation] Sickness behavior発現における中枢プロスタグランジンDP2受容体の選択的役割 (2010)
  • Author(s): 新谷紀人, 他
  • Organizer: 第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
  • Place of Presentation: 宮城
  • Year and Date: 20100915-20100917
• [Presentation] Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration behavior (2010)
  • Author(s): Haba R, Shintani N, et al.
  • Organizer: Neuro2010(第33回日本神経科学会・第53回日本神経化学会・第20回日本神経回路学会合同大会)
  • Place of Presentation: 神戸
  • Year and Date: 20100902-20100904
• [Presentation] Specific involvement of prostaglandin D2 signaling in the light-induced phase advance of circadian rhythm (2010)
  • Author(s): Shintani N, et al.
  • Organizer: Official Satellite Symposium of the 14th International Congress of Endcrinology (GPCR2010)
  • Place of Presentation: Kyoto Garden Palace, Kyoto(招待シンポジウム)
  • Year and Date: 20100330-20100331
• [Presentation] LPS誘発sickness behaviorに対する新規プロスタノイド受容体CRTH2の関与 (2010)
  • Author(s): 羽場亮太, 新谷紀人, 他
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 20100328-20100330
• [Presentation] Mice lacking L-PGDS showed specific impairment in the light-induced phase advance of locomotor rhythm (2010)
  • Author(s): Hatanaka M, Shintani N, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100316-20100318
• [Presentation] Involvement of novel prostanoid receptor CRTH2 in LPS-induced sickness behaviors (2010)
  • Author(s): Haba R, Shintani N, et al.
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 20100316-20100318
• [Presentation] Lipopolysaccharide腹腔内投与で誘発される精神機能変化の解析 (2010)
  • Author(s): 新谷紀人, 他
  • Organizer: 第60回日本薬学会近畿支部総会・大会
  • Place of Presentation: 大阪
  • Year and Date: 2010-10-30
• [Presentation] 概日リズムの前進性光同調選択的なリポカリン型プロスタグランジンD_2合成酵素(L-PGDS)の関与 (2010)
  • Author(s): 黒見藍, 畑中道賢, 新谷紀人, 他
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2010
  • Place of Presentation: 京都
  • Year and Date: 2010-09-11
• [Presentation] 特定のsickness behavior発現における脳内CRTH2の選択的関与 (2010)
  • Author(s): 羽場亮太, 新谷紀人, 他
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2010
  • Place of Presentation: 京都
  • Year and Date: 2010-09-11
• [Presentation] 強制水泳試験時の行動調節におけるCRTH2の役割 (2010)
  • Author(s): 尾中勇祐, 羽場亮太, 王海波, 新谷紀人, 他
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2010
  • Place of Presentation: 京都
  • Year and Date: 2010-09-11
• [Presentation] II型プロスタグランジンD2受容体(CRTH2/DP_2)の中枢機能 (2010)
  • Author(s): 新谷紀人
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム2010
  • Place of Presentation: 京都
  • Year and Date: 2010-09-11
• [Presentation] CRTH2遺伝子欠損マウスの行動薬理学的特性 (2010)
  • Author(s): 尾中勇祐, 羽場亮太, 新谷紀人, 他
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島
  • Year and Date: 2010-07-08
• [Presentation] 精神行動・情動機能制御における中枢CRTH2の役割 (2010)
  • Author(s): 新谷紀人, 他
  • Organizer: CRTH2研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-02-27
• [Presentation] Identification of a novel signaling cascade specifically involved in the light-induced phase advance of circadian rhythm by using PACAP knockout mice (2009)
  • Author(s): Hatanaka M, Shintani N, et al.
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: 鹿児島
  • Year and Date: 20091004-20091008
• [Presentation] 15-Deoxy-Δ-prostaglandin J_2 enhances NGF-induced neurite outgrowth in PC12 cells via a CRTH2 receptor-p38 MAP kinase pathway (2009)
  • Author(s): Shibata N, Hatanaka M, Shintani N, et al.
  • Organizer: The 9th International Symposium on VIP, PACAP and Related Peptides
  • Place of Presentation: 鹿児島
  • Year and Date: 20091004-20091008
• [Presentation] L-PGDS-PGD2- CRTH2 signaling is a novel signaling cascade specifically involved in light-induced phase advance of circadian rhythm (2009)
  • Author(s): Shintani N, et al.
  • Organizer: 第36回国際生理学会世界大会(IUPS2009)
  • Place of Presentation: 京都
  • Year and Date: 20090727-20090801
• [Presentation] 精神運動機能調節におけるCRTH2受容体の役割に関する行動薬理学的検討 (2009)
  • Author(s): 羽場亮太, 畑中道賢, 新谷紀人, 他
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 20090508-20090509
• [Presentation] Lypopolysaccharide (LPS)誘発sickness behaviorに対するPGD_2・TXA_2受容体拮抗薬ラマトロバンの作用 (2009)
  • Author(s): 王海波, 羽場亮太, 新谷紀人, 他
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: 滋賀
  • Year and Date: 2009-11-13
• [Presentation] PGD_2受容体CRTH2アゴニストのオープンフィールド行動に対する作用 (2009)
  • Author(s): 羽場亮太, 畑中道賢, 新谷紀人, 他
  • Organizer: 第115回日本薬理学会近畿部会
  • Place of Presentation: 金沢
  • Year and Date: 2009-06-26
• [Remarks] ホームページ等
  • URL: http://molpharm.umin.jp/