2010 Fiscal Year Final Research Report
Elucidation of novel mechanisms of obesity and the therapeutic drug -elucidation of leptin resistance-
| Project/Area Number |
21790079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
HOSOI Toru Hiroshima University, 大学院・医歯薬学総合研究科, 講師 (40379889)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小胞体ストレス / 肥満 / レプチン |
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| Research Abstract |
Leptin is mainly secreted from adipose tissue, which subsequently induces anti-obesity action. On the other hand, it has been reported that most of the obesity patients are in the state of "leptin resistance" , which cannot adequately respond to the circulating leptin. At these circumstances, we found the possibility that "endoplasmic reticulum (ER) stress" is involved in the development of leptin resistance. Accumulation of unfolded protein will result in ER stress and increasing evidence has been suggested that ER stress is involved in several types of diseases. In the present study, we found the novel drug, which can reduce ER stress. Moreover, subsequent analysis indicated that this drug could inhibit high-fat diet-induced obesity in mice model.
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