2011 Fiscal Year Final Research Report
Roles of the minor sialic acid molecular species in hippocampal dependent memory
| Project/Area Number |
21790085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
AKIRA Minami 静岡県立大学, 薬学部・生化学教室, 助教 (80438192)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖鎖 / 記憶 / 海馬 / 神経 / シアル酸分子種 / シアリダーゼ / インビボ解析 / 酵素活性イメージング |
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| Research Abstract |
N-Acetylneuraminic acid(Neu5Ac), the major molecular species of sialic acid, is contained in mammalian brain abundantly and plays crucial roles in many neural functions including memory. However, roles of other minor molecular species of sialic acid were poorly understood. In this project, we found the roles of the minor sialic acid molecular species in hippocampal dependent memory.
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