2010 Fiscal Year Final Research Report
Analysis of signal transduction of Polycythemia vera-associated JAK2 V617F mutant
| Project/Area Number |
21790090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
TAGO Megumi Keio University, 薬学部, 講師 (30445192)
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| Project Period (FY) |
2009 – 2010
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| Keywords | JAK2 / V617F点変異 / 真性赤血球増加症 / STAT5 / Akt / Aurora kinase A |
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| Research Abstract |
The constitutively activated mutation of tyrosine kinase JAK2 (V617F) is found in the majority of the patients with polycythemia vera. We found that JAK2 mutant induces transformation through aberrant activation of STAT5. Interestingly, it was found that the expression of Aurora kinase A and activation of Akt were significantly induced by JAK2 mutant. We showed that Aurora kinase A was critical for JAK2 mutant-induced resistance to cisplatin-induced DNA damage. Furthermore, we clarified that Akt activation induced the downregulation of anti-apoptotic proteins, leading to anti-apoptotic activity.
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Research Products
(17 results)
