2010 Fiscal Year Final Research Report
Physiological roles of a novel cannabinoid receptor GPR55 and its endogenous ligand
| Project/Area Number |
21790095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
OKA Saori Teikyo University, 薬学部, 講師 (80439562)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生化学 / 脂質生化学 / カンナビノイド / オーファン受容体 / リゾリン脂質 |
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| Research Abstract |
GPR55 is a putative novel cannabinoid receptor and its endogenous ligand is lysophosphatidylinositol (LPI). This study revealed that LPI plays some essential roles in the regulation of cytoskeletal functions and stress responses. Furthermore, we searched for the ligand for GPR35 which has 30% homology with GPR55, and found that 2-acyl lysophosphatidic acid (LPA) may act as an endogenous ligand for GPR35.
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