2011 Fiscal Year Final Research Report
Development of atopic dermatitis-like itch model using hairless mice
| Project/Area Number |
21790096
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
河野 茂勝 京都薬科大学, 教授(既退職)
奈邉 健 京都薬科大学, 准教授
島崎 裕貴 京都薬科大学, 大学院生(既卒)
多留木 崇志 京都薬科大学, 学部生(既卒)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 痒み / アトピー性皮膚炎 / アレルギー / ドライスキン / 皮膚バリア機能低下 |
|---|
| Research Abstract |
The present study was conducted to develop a new animal model that closely reflects itch in atopic dermatitis. When hairless mice were fed a special diet deficient in unsaturated fatty acids, dry skin accompanied by reduced function of skin barrier was systemically induced. When mite extract-containing ointment was repeatedly applied to the dry skin, skin inflammation with concomitant marked scratching behavior was observed. This model could be useful for elucidating the mechanisms underlying itch in atopic dermatitis and developing novel therapeutics.
|
