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2010 Fiscal Year Final Research Report

The role of uPAR on the LPS-induced bone resorption.

Research Project

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Project/Area Number 21790097
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionDoshisha Women's College of Liberal Arts

Principal Investigator

KANNO Yosuke  Doshisha Women's College of Liberal Arts, 薬学部, 助教 (40416178)

Project Period (FY) 2009 – 2010
KeywordsLPS / uPAR / 炎症性骨破壊
Research Abstract

We found that the absent of uPAR attenuated LPS-induced osteoclast differentiation and bone destruction. In addition, we found that uPAR regulated LPS-induced osteoclast differentiation through NF-kB pathway. Moreover, The inhibitor of integrin pathway attenuated uPAR-increased osteoclasts differentiation. These data suggest that uPAR plays a pivotal role on the LPS-induced osteoclasts differentiation.

  • Research Products

    (7 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Plasminogen/Plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.2011

    • Author(s)
      Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Naoyuki Chosa, Keiichi Nakajima, Tatsuji Nishihara, Kuniaki Toyoshima, Kiyotaka Okada, Shigeru Ueshima, Kenji Matsushita, Osamu Matsuo, Hiroyuki Matsuno
    • Journal Title

      J Biol Chem. 286

      Pages: 8952-8960

    • Peer Reviewed
  • [Journal Article] uPAR is associated with the development of adipose tissue.2010

    • Author(s)
      Yosuke Kanno, Hiroyuki Matsuno, Eri Kawashita, Kiyotaka Okada, Hidetaka Suga, Shigeru Ueshima, Osamu Matsuo
    • Journal Title

      Thrombosis and Heamostasis 104

      Pages: 1124-1132

    • Peer Reviewed
  • [Journal Article] Alpha 2-antiplasmin is associated with the progression of fibrosis.2010

    • Author(s)
      Yosuke Kanno, Eri Kawashita, Misato Minamida, Aki Kaneiwa, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno
    • Journal Title

      Am J Pathol. 176

      Pages: 238-245

    • Peer Reviewed
  • [Presentation] Plasminogen/Plasminは、骨芽細胞と破骨細胞を制御する事によって骨代謝を制御している2010

    • Author(s)
      Yosuke Kanno, Akira Ishisaki, Eri Kawashita, Keiichi Nakajima, Kiyotaka Okada, Shigeru Ueshima, Osamu atsuo, Hiroyuki Matsuno
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20101200
  • [Presentation] Plasmin and a2-antiplasmin modulate bone metabolism by regulating the osteoblast and osteoclast function.2010

    • Author(s)
      Yosuke Kanno, Eri Kawashita, Kiyotaka Okada, Shigeru Ueshima, Osamu Matsuo, Hiroyuki Matsuno
    • Organizer
      The 20th International Congress of the ISFP
    • Place of Presentation
      Amsterdam
    • Year and Date
      20100800
  • [Presentation] 線維化病態におけるalpha2-antiplasminの役割2009

    • Author(s)
      菅野陽介、河下映里、岡田清孝、上嶋繁、松尾理、松野浩之
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20091000
  • [Remarks] ホームページ等

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Published: 2012-02-13   Modified: 2016-04-21  

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