2010 Fiscal Year Final Research Report
Possibility of apelin in ischemic retinal disease as a new target for drug development
| Project/Area Number |
21790098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Setsunan University |
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Principal Investigator |
KASAI Atsushi Setsunan University, 薬学部, 助教 (40454649)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 血管新生 / アペリン / 網膜 / 虚血 / VEGF / siRNA / 硝子体内投与 / ペリサイト |
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| Research Abstract |
Pathological angiogenesis in patients with ischemic retinal diseases such as diabetic retinopathy results in visual loss and blindness, because the newly formed vessels are quite leaky and can cause vitreous hemorrhage. We previously reported that a dramatic upregulation of apelin expression cause exuberant endothelial cell proliferation and pathological angiogenesis in retinas of oxygen-induced retinopathy model. Here, we demonstrate that in vivo delivery of apelin siRNA to retina resulted in suppression of pathological angiogenesis in oxygen-induced retinopathy model.
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Research Products
(15 results)
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[Journal Article] Apelin is a crucial factor for hypoxia-induced retinal angiogenesis.2010
Author(s)
Atsushi Kasai, Yuki Ishimaru, Toshihiko Kinjo, Tatsuya Satooka, Nao Matsumoto, Yasuhiro Yoshioka, Akiko Yamamuro, Fumi Gomi, Norihito Shintani, Akemichi Baba, Sadaaki Maeda
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Journal Title
Arterioscler.Thromb.Vasc.Biol. 30
Pages: 2182-2187
Peer Reviewed
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