2010 Fiscal Year Final Research Report
Involvement of brain pericytes in the development of obesity
| Project/Area Number |
21790102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Fukuoka University |
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Principal Investigator |
TAKATA Fuyuko Fukuoka University, 薬学部, 助教 (70412575)
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| Research Collaborator |
KATAOKA Yasufumi 福岡大学, 薬学部, 教授 (70136513)
DOHGU Shinya 福岡大学, 薬学部, 准教授 (60399186)
MATSUMOTO Junichi 福岡大学, 薬学部, 助教 (10550064)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経生物学 |
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| Research Abstract |
Brain pericytes are periendothelial accessory structures of the blood-brain barrier (BBB) and integral members of the neurovascular unit. Although neuron-glial cell interactions are essential for cerebral functions, an interaction between pericytes and neuron has still unknown. Our results suggested that pericytes would increase insulin sensitivity and decrease production of AgRP in hypothalamic neuron through soluble factors under physiological condition. On the other hand, we demonstrated that BBB permeability was significantly increased at obese mice with impaired glucose tolerance induced by high-fat diet. TNF-α, which is increased in obesity, induced pericyte-derived MMP-9, leading to BBB dysfunction. Therefore, pericytes and pericytal MMP-9 may be involved in BBB dysfunction in and development of obesity.
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[Presentation] NADPH oxidase-derived reactive oxygen species (ROS) facilitate TNF-alpha-induced up-regulation of MMP-9 production in the brain pericytes through Akt activation.2010
Author(s)
Takata F, Dohgu S, Matsumoto J, Machida T, Furuno T, Ichiki N, Kaneshima S, Miyaji H, Tao S, Shuto H, Yamauchi A, Kataoka Y.
Organizer
13th International Blood-Brain Barrier Symposium Zurich
Place of Presentation
Switzerland
Year and Date
2010-09-02
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