2010 Fiscal Year Final Research Report
Pharmacological studies on responsiveness of 5-hydroxytryptamine to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus
| Project/Area Number |
21790104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
TOTORIBE Naoko Kyushu University of Health and Welfare, 薬学部, 講師 (70322576)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬理学 |
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| Research Abstract |
Diabetes mellitus (DM) could enhance 5-HT-induced vasocontraction via the activation of 5-HT2A and 5-HT1B receptors of the human internal thoracic artery (ITA) and saphenous vein (SV). The enhanced vasocontractions to 5-HT in DM were mediated by the activation of Rho/Rho kinase pathways. Insulin inhibited 5-HT-induced vasocontraction in SV. These results inducate the useful pharmacological findings to prevent 5-HT-induced vasospasm when the human ITA and SV from patients with DM were used as an arterial graft.
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