2010 Fiscal Year Final Research Report
Intracellular delivery of therapeutic molecules using functional cell-penetrating peptides that target specific cells
| Project/Area Number |
21790112
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKASE Ikuhiko Kyoto University, 化学研究所, 助教 (40432322)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 膜透過ペプチド / 薬物送達 / 細胞標的 |
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| Research Abstract |
Cell-penetrating peptides (CPPs) have been used as carriers to efficiently deliver various types of molecules that are difficult to internalize into cells by themselves. In this research, to examine cell-specific delivery using functional CPPs bearing specific-molecule target sequences was conducted. Using leucine zipper peptides, we ascertained cell-specific internalization of CPP through target-sequence expressed cell membranes with less cytotoxicity.
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[Journal Article] Enhanced target-specific accumulation of radiolabeled antibodies by conjugating arginine-rich peptides as anchoring molecules.2010
Author(s)
R.Miyamoto, H.Akizawa, T.Nishikawa, T.Uehara, Y.Azuma, I.Nakase, S.Futaki, H.Hanaoka, Y.Iida, K.Endo, Y.Arano.
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Journal Title
Bioconjug. Chem. 21
Pages: 2031-2037
Peer Reviewed
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[Journal Article] Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4.2010
Author(s)
K.Shimane, E.N.Kodama, I.Nakase, S.Futaki, Y.Sakurai, Y.Sakagami, X.Li, T.Hattori, S.G.Sarafianos, M.Matsuoka.
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Journal Title
Int.J.Biochem.Cell Biol. 42
Pages: 1482-1488
Peer Reviewed
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