2011 Fiscal Year Final Research Report
Design, synthesis, and application of carborane-containing functional molecules based upon intermolecular interactions
| Project/Area Number |
21790116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
OHTA Kiminori 東北薬科大学, 薬学部, 講師 (90347906)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医薬分子機能学 |
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| Research Abstract |
A rational combination of high hydrophobicity and acidic C-H hydrogens of carboranes afforded various artificial receptors. Among synthesized anion receptors, tricarborane derivative showed the property of chloride ion channel in chloride transport assay using liposome. Some tricarborane analogues showed a more potent association constant for chloride anion than the parent compound and a different selectivity for various anions. To understand hydrophobic interactions of carborane cages and apply carborane-containing compounds to medicinal drugs, the physicochemical properties about the complexation between cyclodextrins and various carborane derivatives are revealed.
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Research Products
(53 results)
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[Journal Article] Crystal Structure Docking Study and Structure-activity Relationship of Carborane-containing Androgen Receptor Antagonist 3-(12-Hydroxymethyl-1, 12-dicarba-closo-dodecaboran-1-yl) benzonitrile2011
Author(s)
Ohta, K.; Goto, T.; Fujii, S.; Kawahata, M.; Oda, A.; Ohta, S.; Yamaguchi, K.; Hirono, S.; Endo, Y.
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Journal Title
Bioorg. Med. Chem
Volume: 19
Pages: 3540-3548
DOI
Peer Reviewed
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