2010 Fiscal Year Final Research Report
Synthesis of siRNA molecules containing phosphinate type dinucleotide derivatives
| Project/Area Number |
21790119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
HIKISHIMA Sadao Tokyo University of Pharmacy and Life Science, 薬学部, 助教 (70398816)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ゲノム創薬 / siRNA |
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| Research Abstract |
For the production of stable siRNA molecules in vivo, We have designed novel modified siRNA molecules that contain phosphinate type dinucleotide derivatives at 3'-end. Though we examined various synthetic routes of phosphinate type dinucleotide derivatives, we could not find effective synthetic route.
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