2010 Fiscal Year Final Research Report
Examination of nano-particles in mice with drugs or chemicals induced toxicity.
| Project/Area Number |
21790127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Teikyo Heisei University |
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Principal Investigator |
ISODA Katsuhiro Teikyo Heisei University, 薬学部, 講師 (60423117)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬学 / 薬理学 / 衛生 / 環境 / 有害物質 |
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| Research Abstract |
Nanomaterials are used frequently in microelectronics, cosmetics and sunscreen, and research for the development of nanomaterial-based drug delivery systems is promising. Interactions between nano-size materials and drugs that have therapeutic potential need investigating. Here, we investigated whether nano-size materials affect drugs-induced toxicity using inert polystyrene particles, nano-silicaand fullerrene particles, which have been widely used in industrial materials, carbon tertrachloride, a popular anti-tumor agent, cisplatin, and a widely used herbicide, paraquat. The result, inert polystyrene particles and nano-silica particles induced liver injury by using together with the drugs. Our findings suggest that further evaluation on the interaction between nano-size materials and drugs is critical for the pharmaceutical application of nanotechnology.
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[Journal Article] Effect of 70-nm silica particles on the toxicity of acetaminophen, tetracycline, trazodone, and 5-aminosalicylic acid in mice.2011
Author(s)
Li X., Kondoh M., Watari, A., Hasezaki T., Isoda K., Tsutsumi Y., Yagi K.
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Journal Title
Pharmazie 66
Pages: 282-286
Peer Reviewed
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