2010 Fiscal Year Final Research Report
The study of toxic mechanisms of dioxins using selenium-binding protein deficient mouse.
| Project/Area Number |
21790128
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Sojo University (2010)
Kyushu University (2009) |
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Principal Investigator |
ISHIDA Takumi Sojo University, 薬学部, 准教授 (10301342)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ダイオキシン / セレン結合性タンパク質 / 欠損マウス / 卵巣 |
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| Research Abstract |
The biological roles of dioxin-inducible selenium-binding protein (SeBP) remain controversial. To address this issue, the SeBP-deficient mice were developed. The notable differences of phenotype and growth curve were not observed between wild-type and SeBP-deficient mice. However, the ovary weight in adult SeBP-deficient mice was significantly increased compared with that in adult wild-type mice. Thus, it is suggested that SeBP is one of suppressive factors of ovary tumor occurred with aging.
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