2010 Fiscal Year Final Research Report
Regulatory mechanisms of sterol transporters under pathophysiological conditions
| Project/Area Number |
21790143
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TAKADA Tappei The University of Tokyo, 医学部附属病院, 助教 (90376468)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 発現制御 / 薬理学 / 生理学 / 脂質 / トランスポーター |
|---|
| Research Abstract |
Niemann-Pick C1-like 1 (NPC1L1) is known to contribute to the cholesterol absorption in the small intestine and liver and is believed to be a pharmacological target of ezetimibe. As a result of the present study, we succeeded in the construction of human NPC1L1 promoter-driven adenovirus for the expression of human NPC1L1. In addition, it was demonstrated that L-FABP is involved in the positive regulation of the expression of NPC1L1 protein in a post-transcriptional manner. These results would be important to understand the relationship between the pathogenesis of obesity-related diseases and sterol transporters.
|
-
-
[Journal Article] Itraconazole-induced cholestasis : involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.2011
Author(s)
Yoshikado T, Takada T, Yamamoto T, Yamaji H, Ito K, Santa T, Yokota H, Yatomi Y, Yoshida H, Goto J, Tsuji S, Suzuki H.
-
Journal Title
Mol Pharmacol. 79(2)
Pages: 241-250
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
