2010 Fiscal Year Final Research Report
Epigenetic regulation of CYP3A4 gene and individual phenotypic status
| Project/Area Number |
21790151
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
HIROTA Takeshi Kyushu University, 薬学研究院, 助教 (80423573)
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| Project Period (FY) |
2009 – 2010
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| Keywords | エピジェネティクス / 発現制御 |
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| Research Abstract |
We show that DNA methylation in CYP3A4 enhancer region is critically involved in determining the individual hepatic CYP3A4 mRNA level. Chromosome Conformation Capture assay suggested long-range cis-interaction between the enhancer region and the transcription start site.
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