2010 Fiscal Year Final Research Report
Exploration of the drug for metabolic disorders which related to ER stress-induced rupture of adipocytes homeostasis
| Project/Area Number |
21790153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
KAMIYA Tetsuro Gifu Pharmaceutical University, 薬学部, 助教 (60453057)
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| Project Period (FY) |
2009 – 2010
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| Keywords | EC-SOD / 小胞体ストレス / アディポネクチン |
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| Research Abstract |
In this study, we investigated the expression of EC-SOD in 3T3-L1 adipocytes during ER stress conditions to explore the drug for metabolic disorders. We confirmed the reduction of EC-SOD by ER stress, but not of other SOD isozymes. Moreover, we speculated that the expression of EC-SOD was regulated by eIF2α signaling cascades. Overall, we suggested that the regulation of EC-SOD during ER stress conditions might lead to improve metabolic disorders.
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Research Products
(12 results)
