2010 Fiscal Year Final Research Report
Development of novel assay system for the functionality of organic cation transporters using fluorescent probe substrate
| Project/Area Number |
21790155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
OHTA Kinya Nagoya City University, 大学院・薬学研究科, 助教 (90448704)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 医療薬剤学 |
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| Research Abstract |
We successfully demonstrated that DAPI can be efficiently transported by both hMATEs, hMATE1 and hMATE2-K, and hOCT1. By taking advantage of its fluorescent nature, we developed a rapid assay system for the selection of inhibitors, which include potential substrates, of hMATEs and hOCT1.
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