2011 Fiscal Year Final Research Report
Exploration of novel biomarker for diagnosis of early stage of arteriosclerosis
| Project/Area Number |
21790156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
IWAKI Soichiro 名古屋市立大学, 大学院・薬学研究科, 助教 (60399962)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 動脈硬化症 / バイオマーカー / miRNA / PAI-1 / スフィンゴシン1-リン酸 |
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| Research Abstract |
We performed a comprehensive analysis of miRNA expression in the aorta of wild-type and ApoE^<-/-> mice using miRNA expression microarrays, total of 12 miRNAs were identified to be differentially expressed. We also demonstrated here that miR-126 levels in plasma are altered in the coronary artery disease patients. These results suggest that miRNAs are available as a novel biomarker to assess the early stage of arteriosclerosis.
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[Journal Article] Role of down-regulated neutral ceramidase during all-trans retinoic acid induced neuronal differentiation in SH-SY5Y neuroblastoma cells.2012
Author(s)
Kouji Tanaka, Keiko Tamiya-Koizumi, Kazumi Hagiwara, Hiromi Ito, Akira Takagi, Tetsuhito Kojima, Motoshi Suzuki, Soichiro Iwaki, Satoshi Fujii, Mitsuhiro Nakamura, Yoshiko Banno, Reiji Kannagi, Tatsuya Tsurumi, Mamoru Kyogashima, Takashi Murate.
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Journal Title
J. Biochem.
Volume: (in press)
Peer Reviewed
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[Journal Article] Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.2012
Author(s)
Tomonori Sugiura, Yasuaki Dohi, Sumiyo Yamashita, Nobuyuki Ohte, Shiori Ito, Soichiro Iwaki, Yuji Hirowatari, Ryunosuke Ohkawa, Yuko Mishima, Yutaka Yatomi, Genjiro Kimura, Satoshi Fujii.
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Journal Title
Coron. Artery Dis.
Volume: 23
Pages: 234-238
Peer Reviewed
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