2010 Fiscal Year Final Research Report
Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factors
| Project/Area Number |
21790160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
SHIMIZU Makiko Showa Pharmaceutical University, 薬学部, 助教 (90307075)
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| Project Period (FY) |
2009 – 2010
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| Keywords | FMO3 / trimethylaminuria / genetic polymorphism / Japanese |
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| Research Abstract |
The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of a wide variety of compounds containing sulfur or nitrogen atoms. FMO3 plays a role in processing some drugs, addictive chemical nicotine and diet-derived trimethylamine. Inter-individual variations of FMO3 are suggested to be co-regulated by trans-acting factors of FMO3 gene.
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