2010 Fiscal Year Final Research Report
Transport mechanisms of opioid analgesics across the blood-brain barrier
| Project/Area Number |
21790162
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
OKURA Takashi Teikyo University, 薬学部, 准教授 (80326123)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬物動態学 |
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| Research Abstract |
An organic cation/proton antiporter is involved in the CNS acting cationic drug transport in the human blood-brain barrier model cells, suggesting that the proton antiporter mediates oxycodone transport into the brain across the blood-brain barrier in humans as well as rodents. Further, we showed that functions of organic cation-related transporters are able to be suppressed by small interfering RNA (siRNA). The siRNA screening method should be useful for the identification of the proton antiporter molecule which mediates blood-to-brain transport of oxycodone.
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