2010 Fiscal Year Final Research Report
Dose adjustment based on the developmental changes of drugmetabolic enzyme activity
| Project/Area Number |
21790170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima International University |
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Principal Investigator |
TAYAMA Yoshitaka Hiroshima International University, 薬学部, 講師 (80389121)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小児 / 胎児 / 新生児 / 薬物代謝 / 医薬品適正使用 |
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| Research Abstract |
In the present study, we observed the developmental changes of drag metabolic enzyme, xanthine oxidase (XO) and aldehyde oxidase (AO) activity in postnatal rat liver. On the other hands, there were no developmental changes of rat placenta XO and AO activity during gestational period. Account for the change of placenta weight, their activity in whole body may change during gestational period. Threfore, we should make dose adjustment based on the developmental changes of drag metabolic enzyme activity.
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