2010 Fiscal Year Final Research Report
Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
| Project/Area Number |
21790178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kanazawa University |
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Principal Investigator |
ISHIMURA Akihiko Kanazawa University, がん研究所, 助教 (80375261)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 癌 / 遺伝子 / 発生・分化 / 細胞増殖 |
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| Research Abstract |
In order to identify novel cancer-related genes, we have performed the retroviral insertional mutagenesis in mice, resulting in identification of Jmjd5, a histone demethylase. In this study, we have generated Jmjd5-deficient mice to investigate in vivo role of Jmjd5. Our results showed that Jmjd5 was involved in embryonic cell proliferation and that Cdkn1a might be one of Jmjd5 targets.
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