2010 Fiscal Year Final Research Report
Analysis of the interaction of STB with steroid hormone receptors and their subcellular dynamics
| Project/Area Number |
21790182
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
FUJINAGA Ryutaro Yamaguchi University, 大学院・医学系研究科, 講師 (30335723)
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| Project Period (FY) |
2009 – 2010
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| Keywords | HAP1 / ハンチントン病 / ステロイド受容体 / タイムラプス / プロテアソーム |
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| Research Abstract |
STB interacted with androgen receptor (AR) and glucocorticoid receptor (GR) through their ligand-binding domain in the cytoplasm. The ligand-dependent nuclear translocation of the receptors on STB was attenuated by the treatment of a proteasome inhibitor. The results suggested that STB is involved in the regulation of the cytoplasmic modification and nuclear translocation of AR and GR in a ubiquitin-proteasome system.
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