2010 Fiscal Year Final Research Report
Unique cell movement of isolated embryonic cells during amphibian gastrulation
| Project/Area Number |
21790190
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Saitama Medical University |
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Principal Investigator |
TAKANO Kazuhiro Saitama Medical University, 医学部, 講師 (80364769)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 両生類 / 原腸陥入 / 形態形成 / 細胞運動 / カルシウムイオン / カルシウムイオンチャネル / 細胞骨格 |
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| Research Abstract |
Mechanisms of unique cell movement of isolated gastrula cells and roles of this movement in morphogenetic cell movement during gastrulation were studied in amphibian gastrulae. Cell biological study revealed that intracellular Ca2+ concentration changes and actin polymerization play in the unique cell movement of isolated gastrula cells and morphogenetic cell movement of intact gastrula. The present study suggested that development and formation of the Ca2+ signaling mechanisms in embryonic cells during gastrulation play an important role in the initiation and execution of morphogenetic cell movement during gastrulation.
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[Journal Article] Development of Ca^<2+> signaling mechanisms and cell motility in presumptive ectodermal cells during amphibian gastrulation.2011
Author(s)
Takano, K., Obata, S., Komazaki, S., Masumoto, M., Oinuma, T., Ito, Y., Ariizumi, T., Nakamura, H., Asashima, M.
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Journal Title
Development Growth & Differentiation 53
Pages: 37-47
Peer Reviewed
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