2010 Fiscal Year Final Research Report
Functional analysis of LC3A, mammalian ortholog of yeast autophagy-related gene Atg8
| Project/Area Number |
21790192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Juntendo University |
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Principal Investigator |
SASAKI Mitsuho Juntendo University, 医学部, 助教 (20432536)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞機能形態学 |
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| Research Abstract |
A microtubule-associated protein 1 light chain 3 (MAP1LC3) is an essential factor of autophagosomal membrane formation. The amino acid sequence of LC3A is highly similar to that of LC3B, but the functional property of LC3A is still unknown. To characterize the function of LC3A, we generated LC3A conditional knockout mice.
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Research Products
(5 results)
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[Journal Article] LC3, a microtubule-associated protein 1A/B light chain 3, is involved in cytoplasmic lipid droplet formation.2010
Author(s)
Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama Y.
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Journal Title
Biochemical and Biophysical Research Communication vol.393
Pages: 274-279
Peer Reviewed
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