2011 Fiscal Year Final Research Report
A new approach to determine a mechanism of trigeminal placode specificity and analysis of molecular mechanism of the placode induction.
| Project/Area Number |
21790193
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | プラコード形成 |
|---|
| Research Abstract |
Epiderm-like cells that are madefrom a chicken neural plate explant are the embryonic ectoderm characteristically expressing a neural plate border specifier Dlx5, which non-cell autonomously controlsthe border of the neural crest and the pre-placodal ectoderm. The epiderm-like cells can be formed only when BMP4 and FGF2 are added into the medium of the explant, and this neural plate explant culture system would help to elucidatea stepwise induction and differentiation mechanismof the placode in the embryo.
|
Research Products
(8 results)
