2011 Fiscal Year Final Research Report
Analysis of the relationship between chemosensitive responses of the cardiovascular neurons and hypoxia
| Project/Area Number |
21790196
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 循環調節 / 高血圧 / 交感神経 / 化学受容器 / 低酸素 |
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| Research Abstract |
This project demonstrated that cardiovascular neurons have chemosensitivity into hypoxia. In order to investigate into the cause of hypertension, I also established the current clamp recording of the functionally identified cardiovascular neurons in the in situ arterially perfused preparation of rats. We also compared synaptic inputs into the cardiovascular neurons in normotensive and hypertensive rats. As a result, it is suggested that inhibitory inputs into the cardiovascular neurons are attenuated in the hypertensive rats compared to normotensive rats.
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