2010 Fiscal Year Final Research Report
Structural and functional analyses of the assembly modules of ion channels for artificial protein design
| Project/Area Number |
21790201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 |
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| Research Abstract |
We analyzed the high-resolution crystal structure of the assembly domain of the voltage-gated H+ channel dimer. Electrophysiological analysis revealed that the temperature-sensitivity of the channel and the functional cooperativity within the dimer are regulated by the assembly domain. We also succeeded in modulating the channel function by mutating the assembly characteristic. Our results shed light on the artificial ion channel design.
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