Research on the activation mechanism of volume-sensitive ion channels in neurons and glia

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790216
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: AKITA Tenpei National Institute for Physiological Sciences, 細胞器官研究系, 特任助教 (00522202)
• Project Period (FY): 2009 – 2010
• Keywords: 細胞容積調節 / イオンチャネル / アストログリア / ブラジキニン / カルシウムイオン / カルシウムナノドメイン / 活性酸素種 / 細胞間情報伝達

Research Abstract

We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.

Research Products

• [Journal Article] Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca^<2+> nanodomains in mouse astrocytes. (2011)
  • Author(s): Akita T, Okada Y
  • Journal Title: The Journal of Physiology In press
  • Peer Reviewed
• [Journal Article] Bradykinin-induced astrocyte-neuron signalling : glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels. (2009)
  • Author(s): Liu HT, Akita T, Shimizu T, Sabirov RZ, Okada Y
  • Journal Title: The Journal of Physiology 587(10) Pages: 2197-2209
  • Peer Reviewed
• [Presentation] Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying (VSOR) anion channels via "Ca^<2+> nanodomains" in mouse cortical astrocytes. (2010)
  • Author(s): 秋田天平(発表代表者)
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市民文化ホール・マリオス(岩手県)
  • Year and Date: 2010-05-21
• [Presentation] Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying (VSOR) anion channels via "Ca^<2+> nanodomains" in mouse cortical astrocytes. (2009)
  • Author(s): 秋田天平(発表代表者)
  • Organizer: 第40回生理学研究所国際シンポジウムPAT-CVR2009
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 20090803-20090806
• [Presentation] 「Ca^<2+>ナノドメイン」を介するブラジキニン誘起性アストログリア細胞容積センサー外向整流性アニオンチャネル(VSOR)活性化機構 (2009)
  • Author(s): 秋田天平(発表代表者)
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2009-12-04
• [Presentation] Bradykinin-induced glutamate release via volume-sensitive outwardly rectifying (VSOR) anion channels in mouse cortical astrocytes. (2009)
  • Author(s): 秋田天平(発表代表者)
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-07-31
• [Remarks] ホームページ等(論文(2)に関して)
  • URL: http://www.nips.ac.jp/contents/release/entry/2009/02/vsor.html