2010 Fiscal Year Final Research Report
Identification of novel ER stress responsive pathways that function in intercellular interaction
| Project/Area Number |
21790218
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IWAWAKI Takao The Institute of Physical and Chemical Research, 中野生体膜研究室, 客員主管研究員 (50342754)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 小胞体ストレス / 血管新生 / 胎盤 / 膵臓 / 糖尿病 / 唾液腺 / タンパク質品質管理 |
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| Research Abstract |
Endoplasmic reticylum (ER) stress has actively been studied at the intracellular level so far. In this research, the purpose is to study the role of ER stress response at the intercellular level and in vivo level. By using in vivo stress imaging and gene targeting technologies, we found that ER stress responsive molecules are essential for the function of the placenta, the salivary gland, and the pancreas. Especially we performed detail investigation for activation of vascular endothelial growth factor in the placenta.
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[Journal Article] The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.2010
Author(s)
Hirato Tsukano, Tomomi Gotoh, Motoyoshi Endo, Miyata Keishi, Hirokazu Tazume, Tsuyoshi Kadomatsu, Masato Yano, Takao Iwawaki, Kenji Kohno, Kimi Araki, Hiroshi Mizuta, Yuichi Oike
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Journal Title
Arterioscler. Thromb. Vasc.Biol. vol.30
Pages: 1925-1932
Peer Reviewed
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