Voluntary exercise linked with cerebral activation and baroreflex control of heart rate : its relation to motivated locomotion

2010 Fiscal Year Final Research Report

• Project/Area Number: 21790224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Shinshu University
• Principal Investigator: MASUKI Shizue Shinshu University, 大学院・医学系研究科, 助教 (70422699)
• Project Period (FY): 2009 – 2010
• Keywords: 自発運動 / vasopressin V1a受容体 / 血圧反射 / 脳波 / 脳血流

Research Abstract

[Control study] We continuously measured cerebral activity and baroreflex control of HR in freely moving control mice. We found that cerebral activation suppressed baroreflex control of heart rate (HR) in their daily life, and after these sequential responses, mice started to move at 5 times higher probability than after a given time, suggesting tight linkages between cerebral activity, baroreflex control of HR, and voluntary locomotion. [V1a knockout study] We assessed any role of vasopressin V1a receptor in these sequential responses. We continuously measured the variables mentioned above in V1a receptor knockout (KO) and wild-type mice (WT). We found that suppression of baroreflex control of HR in response to voluntary activation of the cerebral cortex was abolished in KO mice. Moreover, the probability that mice started to move after cerebral activation was markedly lower in KO than WT mice with less suppression of baroreflex control of HR. These results suggest that V1a receptor plays an important role in starting voluntary locomotion after cerebral activation through suppression of baroreflex control of HR.

Research Products

• [Journal Article] Effects of hypohydration on thermoregulation during exercise before and after 5-day aerobic training in a warm environment in young men. (2011)
  • Author(s): Ikegawa S, Kamijo Y, Okazaki K, Masuki S, Okada Y, Nose H.
  • Journal Title: J Appl Physiol 110 Pages: 972-980
  • Peer Reviewed
• [Journal Article] Physical fitness and indices of lifestyle-related diseases before and after interval walking training in middle-aged and older males and females. (2011)
  • Author(s): Morikawa M, Okazaki K, Masuki S, et al.
  • Journal Title: Br J Sports Med 45 Pages: 216-224
  • Peer Reviewed
• [Journal Article] Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people. (2010)
  • Author(s): Masuki S, Mori M, Tabara Y, Miki T, Sakurai A, Morikawa M, Miyagawa K, Higuchi K, Nose H
  • Journal Title: Hypertension 55 Pages: 747-754
  • Peer Reviewed
• [Journal Article] Protein and carbohydrate supplementation during 5-day aerobic training enhanced plasma volume expansion and thermoregulatory adaptation in young men. (2010)
  • Author(s): Goto M, Okazaki K, Kamijo Y, Ikegawa S, Masuki S, Miyagawa K, Nose H.
  • Journal Title: J Appl Physiol 109 Pages: 1247-1255
  • Peer Reviewed
• [Journal Article] Sportology and high intensity interval walking training in aging society. (2010)
  • Author(s): Nose H, Morikawa M, Masuki S, Yamazaki T, Nemoto K, Okazaki K, Kmaijo Y, Genno H.
  • Journal Title: Juntendo Med J 56 Pages: 251-256
  • Peer Reviewed
• [Journal Article] Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice. (2009)
  • Author(s): Masuki S, Nose H.
  • Journal Title: J Physiol (Lond) 587 Pages: 5783-5794
  • Peer Reviewed
• [Journal Article] Beyond epidemiology: field studies and the physiology laboratory as the whole world. (2009)
  • Author(s): Nose H, Morikawa M, Yamazaki T, Nemoto K, Okazaki K, Masuki S, Kamijo Y, Gen-no H.
  • Journal Title: J Physiol (Lond) 587 Pages: 5569-5575
  • Peer Reviewed
• [Journal Article] Impact of protein and carbohydrate supplementation on plasma volume expansion and thermoregulatory adaptation by aerobic training in older men. (2009)
  • Author(s): Okazaki K, Ichinose T, Mitono H, Chen M, Masuki S, Endoh H, Hayase H, Tatsuya Doi T, Nose H.
  • Journal Title: J Appl Physiol 107 Pages: 725-733
  • Peer Reviewed
• [Journal Article] Pressor responses to isometric biting are evoked by somatosensory receptors in periodontal tissue in humans. (2009)
  • Author(s): Okada Y, Kamijo Y, Okazaki K, Masuki S, Goto M, Nose H.
  • Journal Title: J Appl Physiol 107 Pages: 531-539
  • Peer Reviewed
• [Journal Article] A new device to estimate VO2 during incline walking by accelerometry and barometry. (2009)
  • Author(s): Yamazaki T, Gen-no H, Kamijo Y, Okazaki K, Masuki S, Nose H.
  • Journal Title: Med Sci Sports Exerc 41 Pages: 2213-2219
  • Peer Reviewed
• [Presentation] Reduced voluntary locomotion linked with cerebral activation in vasopressin V1a receptor knockout mice. (2010)
  • Author(s): Masuki S, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, Nose H.
  • Organizer: The 87th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka, Japan(招待講演, 国内会議)
  • Year and Date: 20100519-20100521
• [Presentation] Behavioral effects of vasopressin V1a receptor gene on voluntary exercise in humans and mice. (2010)
  • Author(s): Masuki S, Nose H.
  • Organizer: Workshop on Probing the Future of Muscle Study in the Institute of Science and Engineering, Ritsumeikan University.
  • Place of Presentation: Ritsumeikan Univ., Kusatsu, Japan(招待講演, 国際会議)
  • Year and Date: 2010-10-22
• [Presentation] Vasopressin V1a receptor polymorphism and adherence to long-term interval walking training in middle-aged and older people. (2010)
  • Author(s): Masuki S, Nose H.
  • Organizer: The 3rd International Sports Sciences Symposium on "Active Life".
  • Place of Presentation: Waseda Univ., Tokyo, Japan(招待講演, 国際会議)
  • Year and Date: 2010-09-25
• [Presentation] Vasopressin V1a receptor and metabolism in humans and mice. (2009)
  • Author(s): Masuki S, Nose H.
  • Organizer: International Sports Science Network Forum in Nagano 2009
  • Place of Presentation: Karuizawa, Japan(招待講演, 国際会議)
  • Year and Date: 20090801-20090803
• [Presentation] Increase in respiratory quotient at night is blunted in vasopressin V1a receptor knockout mice. (2009)
  • Author(s): Masuki S, Koshimizu T, Qian J, Higuchi K, Tsujimoto G, Nose H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan, J Physiol Sci 59, S221, 2009(一般発表)
  • Year and Date: 20090727-20090801
• [Presentation] Vasopressin V1a receptor polymorphism and high-intensity interval walking training effects in middle-aged and older people. (2009)
  • Author(s): Masuki S, Mori M, Tabara Y, Miki T, Morikawa M, Miyagawa K, Higuchi K, Nose H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan. J Physiol Sci 59, S357, 2009(一般発表)
  • Year and Date: 20090727-20090801
• [Presentation] Enhanced skin blood flow response to hyperthermia after endurance training is mainly caused by plasma volume expansion in humans. (2009)
  • Author(s): Ikegawa S, Kamijo Y, Okazaki K, Masuki S, Okada Y, Nose H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan. J Physiol Sci 59, S220, 2009(一般発表)
  • Year and Date: 20090727-20090801
• [Presentation] Sympathetic vasoconstrictor responsiveness is reduced by 5-day endurance training with enhanced baroreflex sensitivity in men. (2009)
  • Author(s): Okazaki K, Kamijo Y, Masuki S, Ikegawa S, Okada Y, Yazawa D, Hata T, Shiba, Y, Takahashi M, Ikeda U, Nose H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan. J Physiol Sci 59, S220, 2009(一般発表)
  • Year and Date: 20090727-20090801
• [Presentation] The effects of sleep bruxism on baroreflex control of the circulation in humans. (2009)
  • Author(s): Okada Y, Kamijo Y, Masuki S, Okazaki K, Nose H.
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan. J Physiol Sci 59, S498, 2009(一般発表)
  • Year and Date: 20090727-20090801