2011 Fiscal Year Final Research Report
The cellular and molecular mechanism of an environmental therapy to prevent the cognitive decline in aging
| Project/Area Number |
21790229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Toyama (2010-2011)
Showa Pharmaceutical University (2009) |
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Principal Investigator |
MIYAMOTO Yoshiaki 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (20449101)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経科学 / 老化 / 学習記憶 / 環境訓練 |
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| Research Abstract |
The hippocampus-dependent cognitive decline in aged mice was improved by enriched environmental training. In the hippocampus of these trained-aged mice, there were significant changes in the expression level of about twenty kinds of protein including basic fibroblast growth factor(bFGF). When bFGF was continuously infused into the hippocampus of aged mice, the cognitive decline was suppressed. These results suggest that the activation of bFGF signal in the hippocampus via the enriched environmental training prevents the decline of learning and memory in normal aging.
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[Journal Article] Periocular injection of in situ hydrogels containing Leu-Ile, an inducer for neurotrophic factors, promotes retinal ganglion cell survival after optic nerve injury2011
Author(s)
Nakatani M., Shinohara Y., Takii M., Mori H., Asai N., Nishimura S., Furukawa-Hibi Y., Miyamoto Y., and Nitta A.
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Journal Title
Exp. Eye Res.
Volume: 93
Pages: 873-879
Peer Reviewed
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