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2010 Fiscal Year Final Research Report

The role of the excitatory action of GABA in the mouse estrous cycle.

Research Project

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Project/Area Number 21790234
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionGunma University (2010)
National Institute for Physiological Sciences (2009)

Principal Investigator

WATANABE Miho  群馬大学, 先端科学研究指導者育成ユニット, 助教 (10399321)

Project Period (FY) 2009 – 2010
KeywordsGnRH / GABA / KCC2 / 性周期
Research Abstract

I investigated the functional consequences of excitatory action of GABA responses on GnRH neuron physiology. A transgenic mouse was generated using tetracycline controlled gene expression system. In this mouse, KCC2 was overexpressed restricted in GnRH neurons reversibly in specific time point. This transgenic mouse could not show the pregnancy. These results suggested that the excitatory action of GABA in GnRH neurons has the important role in the regulation of the estrous cycle.

  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results) Remarks (1 results)

  • [Journal Article] Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride.2010

    • Author(s)
      Nakahata Y, Miyamoto A, Watanabe M, Moorhouse A J, Nabekura J
    • Journal Title

      Brain Research

      Volume: 1345 Pages: 19-27

    • Peer Reviewed
  • [Journal Article] Clustering of neuronal K^+ -Cl^- cotransporters in lipid rafts by tyrosine phosphorylation.2009

    • Author(s)
      Watanabe M, Wake H, Moorhouse A, Nabekura J
    • Journal Title

      Journal of Biological Chemistry

      Volume: 284 Pages: 27980-27988

    • Peer Reviewed
  • [Journal Article] GABA A receptors mediate excitation in adult rat GnRH neurons.2009

    • Author(s)
      Watanabe M*, Sakuma Y, Kato M
    • Journal Title

      Biology of Reproduction

      Volume: 81 Pages: 327-332

    • Peer Reviewed
  • [Presentation] 発達/傷害によるカリウム-クロライド共役担体(KCC2)の機能制御2011

    • Author(s)
      渡部美穂、鍋倉淳一
    • Organizer
      第1回放射線神経生物学研究集会
    • Place of Presentation
      群馬大学(群馬県)
    • Year and Date
      2011-01-29
  • [Presentation] 生体脳においてGABA_A受容体の活性化は大脳皮質辺縁帯GABA作動性神経 細胞の多方向性移動を促進する2010

    • Author(s)
      稲田浩之、渡部美穂、内田琢、福田敦夫、柳川右千夫、鍋倉淳一
    • Organizer
      第57回中部日本生理学会大会
    • Place of Presentation
      藤田保健衛生大学(愛知県)
    • Year and Date
      2010-10-16
  • [Presentation] リドカインによるK^+-Cl^-共輸送体(KCC2)の機能抑制2010

    • Author(s)
      中畑義久、宮本愛喜子、渡部美穂、鍋倉淳一、石橋仁
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県)
    • Year and Date
      2010-09-03
  • [Presentation] チロシンリン酸化による神経特異的カリウムークロール共役担体の機能制御2010

    • Author(s)
      鍋倉淳一、渡部美穂
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市民文化ホール(岩手県)
    • Year and Date
      2010-05-21
  • [Presentation] Modulation of KCC2 function by tyrosine phosphorylation.2010

    • Author(s)
      Moorhouse A, Watanabe M, Wake H, Nabekura J
    • Organizer
      The 30th Annual Meeting of the Australian Neuroscience Society/ the 50th Anniversary Meeting of the Australian Physiological Society
    • Place of Presentation
      Sydney convention & Exhibition Centre (Australia)
    • Year and Date
      2010-02-01
  • [Presentation] Clustering of neuronal K^+-Cl^- cotransporter in the lipid rafts by tyrosine phosphorylation.2009

    • Author(s)
      Watanabe M, Wake H, Nabekura J
    • Organizer
      40th NIPS International Symposium-International Joint Symposium : PAT-CVR
    • Place of Presentation
      岡崎コンファレンスセンター (愛知県)
    • Year and Date
      2009-08-05
  • [Presentation] Functional regulation of neuronal K-Cl transporter by tyrosine phosphorylation.2009

    • Author(s)
      Nabekura J and Watanabe M
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-08-01
  • [Remarks]

    • URL

      http://asrldu.dept.med.gunma-u.ac.jp/mwatanabe/miho_watanabe.html

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Published: 2013-07-31  

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