2010 Fiscal Year Final Research Report
Clarification of insulin/IGF-I receptor signal expression mechanism
| Project/Area Number |
21790244
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
NEMOTO Takayuki University of Miyazaki, 医学部, 助教 (90506833)
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| Project Period (FY) |
2009 – 2010
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| Keywords | インスリン受容体 / IGF-I受容体 / IRS / GSK-3β / mTOR / tau / Nav1.7 |
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| Research Abstract |
We clarified (1) IRS expression by Hsp90 ; (2) up-regulation of Nav1.7 by GSK-3β inhibition ; (3) IGF-I-induced homologous regulation of IGF-I receptor expression via GSK-3βand mTOR ; and (4) decrease of phosphorylated tau via GSK-3β inhibition by Na+ influx-induced activations of PI3K-Akt and PKC-α-ERK/p38 pathways.
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