2010 Fiscal Year Final Research Report
Search of regulatory factors in neural glutathione concentration
| Project/Area Number |
21790251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
WATABE Masahiko Teikyo University, 医学部, 講師 (90301788)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 脳・神経 / 脳神経疾患 / ストレス |
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| Research Abstract |
Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as a Parkinson's disease. Neurons rely mainly on extracellular cysteine for glutathione synthesis and a cysteine transporter termed excitatory amino acid carrier-1 (EAAC1). I previously showed GTRAP3-18 (glutamate transport associated protein for EAAC1) to interact with EAAC1 and thereby regulate neuronal glutathione levels. In this time, I indicated the phosphorylation of GTRAP3-18, which is a key of information to search regulatory factors in neural glutathione concentration.
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