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2010 Fiscal Year Final Research Report

Effect of running wheel on methamphetamine abuse in mice : a possible pharmacotherapy for drug abuse by environmental enrichment

Research Project

  • PDF
Project/Area Number 21790254
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionHyogo College of Medicine

Principal Investigator

KITANAKA Nobue  Hyogo College of Medicine, 医学部, 講師 (30340954)

Project Period (FY) 2009 – 2010
Keywords薬物治療 / トキシコロジー
Research Abstract

We investigated whether environmental enrichment (i.e. exposure to a running wheel) affected methamphetamine (METH) effects, such as hyperlocomotion and abuse, in mice. Gradually increasing running wheel activity was observed over three consecutive days after exposure to a running wheel with no effects on their food or water intakes. Exposure to the running wheel did not affect METH-induced hyperlocomotion or development of abuse, but the exposure accelerated the extinction of METH abuse.

  • Research Products

    (11 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Withdrawal from fixed-dose injection of methamphetamine decreases cerebral levels of 3-methoxy-4-hydroxyphenylglycol and induces the expression of anxiety-related behavior in mice.2010

    • Author(s)
      Kitanaka, N., Kitanaka, J., Tatsuta, T., Tanaka, K., Watabe, K., Nishiyama, N., Morita, Y., Takemura, M.
    • Journal Title

      Neurochem. Res. 35(5)

      Pages: 749-760

    • Peer Reviewed
  • [Journal Article] Low-dose pretreatment with clorgyline decreases the levels of 3-methoxy-4-hydroxyphenylglycol in the striatum and nucleus accumbens and attenuates methamphetamine-induced conditioned place preference in rats.2010

    • Author(s)
      Kitanaka, N., Kitanaka, J., Watabe, K., Takemura M.
    • Journal Title

      Neuroscience 165(4)

      Pages: 1370-1376

    • Peer Reviewed
  • [Journal Article] Pretreatment with L-histidine produces a shift from methamphetamine-induced stereotypical biting to persistent locomotion in mice2010

    • Author(s)
      Kitanaka J., Kitanaka N., Tatsuta T., Miyoshi A., Koumoto A., Tanaka K., Nishiyama N., Morita Y., Takemura M.
    • Journal Title

      Pharmacol. Biochem. Behav. 94(3)

      Pages: 464-470

    • Peer Reviewed
  • [Journal Article] Histamine H_3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine.

    • Author(s)
      Kitanaka, J., Kitanaka, N., Hall, F.S., Uhl, G.R., Tatsuta, T., Morita, Y., Tanaka, K., Nishiyama, N., Takemura, M.
    • Journal Title

      Neurochem. Res. In press

    • Peer Reviewed
  • [Presentation] 回転皿の経験が覚せい剤誘導場所嗜好性に及ぼす影響2011

    • Author(s)
      北中順惠, 北中純一, 渡部要, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20110316-20110318
  • [Presentation] 視床下部ヒスタミン含量変化と覚せい剤誘発常同噛み行動の発現頻度との関連性2011

    • Author(s)
      北中純一, 北中順惠, F.Scott Hall, George R.Uhl, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20110316-20110318
  • [Presentation] マウスにおける覚せい剤報酬効果、自発運動量亢進、および常同行為に対するイソリキリチゲニン(甘草フラボノイド)の効果2011

    • Author(s)
      北中純一, 北中順惠, 岡本正幸, 南弘樹, 田中康一, 立田知大, 守田嘉男, 西山信好, 竹村基彦
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20110316-20110318
  • [Presentation] マウスにおける覚せい剤誘発常同噛み行動の調節にヒスタミン神経系が関与する2010

    • Author(s)
      北中純一, 北中順惠, 河本あてな、三好晶雄、田中康一, 西山信好, 立田知大, 守田嘉男, 竹村基彦
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20100902-20100904
  • [Presentation] マウスにおける覚せい剤処置後の行動および脳内モノアミン含量に対する回転皿の影響2010

    • Author(s)
      北中順惠, 北中純一, 渡部要、田中康一, 立田知大, 西山信好, 守田嘉男, 竹村基彦
    • Organizer
      第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20100902-20100904
  • [Presentation] マウスにおける豊かな環境と覚せい剤誘発行動との関連2010

    • Author(s)
      北中順惠, 北中純一, 渡部要, 立田知大, 田中康一, 西山信好, 守田嘉男, 竹村基彦
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      20100316-20100318
  • [Book] Sequential expression of impaired psychomotor activities in rodents during amphetamine withdrawal.(Editor, Davies, RS.ed.)(In : Chapter 4.Handbook of Neuropsychiatry Research)(New York)2010

    • Author(s)
      Kitanaka, J., Kitanaka, N., Takemura, M.
    • Total Pages
      79-90
    • Publisher
      Nova Science Publishers, Inc.

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Published: 2012-02-13   Modified: 2016-04-21  

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