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2010 Fiscal Year Final Research Report

Mechanism of vascular dysfunction induced by the interaction of CRP and LOX-1

Research Project

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Project/Area Number 21790259
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

FUJITA Yoshiko  独立行政法人国立循環器病研究センター, 血管生理学部, 研究員 (30416218)

Project Period (FY) 2009 – 2010
Keywords心血管 / 血液
Research Abstract

(No Summary)

  • Research Products

    (23 results)

All 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (13 results) Remarks (1 results)

  • [Journal Article] Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox2011

    • Author(s)
      Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R., Sawamura, T.
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci 87(3)

      Pages: 104-113

    • Peer Reviewed
  • [Journal Article] LOX-1 mediates vascular lipid retention under hypertensive state2010

    • Author(s)
      Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H., Sawamura, T.
    • Journal Title

      J Hypertens 28(6)

      Pages: 1273-1280

    • Peer Reviewed
  • [Journal Article] Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans2010

    • Author(s)
      Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K., Horie, M.
    • Journal Title

      Lipids 45(4)

      Pages: 329-335

    • Peer Reviewed
  • [Journal Article] Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts2010

    • Author(s)
      Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T., Hasegawa, K.
    • Journal Title

      Circ J 74(4)

      Pages: 723-729

    • Peer Reviewed
  • [Journal Article] LOX index, a novel predictive biochemical marker for coronary heart disease and stroke2010

    • Author(s)
      Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R., Sawamura, T.
    • Journal Title

      Clin Chem 56(4)

      Pages: 550-558

    • Peer Reviewed
  • [Journal Article] C-reactive protein uptake by macrophage cell line via class-A scavenger receptor2010

    • Author(s)
      Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R., Sawamura, T.
    • Journal Title

      Clin Chem 56(3)

      Pages: 478-481

    • Peer Reviewed
  • [Journal Article] LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells2009

    • Author(s)
      Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y., Takeishi, Y.
    • Journal Title

      Cardiovasc Res 84(1)

      Pages: 127-136

    • Peer Reviewed
  • [Journal Article] Lox-1 : the multifunctional receptor underlying cardiovascular dysfunction2009

    • Author(s)
      Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R., Sawamura, T.
    • Journal Title

      Circ J 73(11)

      Pages: 1993-1999

    • Peer Reviewed
  • [Journal Article] Oxidized LDL receptor LOX-12009

    • Author(s)
      Fujita, Y., Sawamura, T.
    • Journal Title

      Nippon Yakurigaku Zasshi 133(5)

      Pages: 295-296

    • Peer Reviewed
  • [Presentation] プロシアニジンはLOX-1アンタゴニストであり、血管壁への脂質沈着を抑制する2011

    • Author(s)
      善本亮、西塚太一、藤田佳子、佐藤優子、中野厚史、垣野明美、大嶋俊二、神田智正、沢村達也
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      誌上開催
    • Year and Date
      2011-03-23
  • [Presentation] 酸化LDL測定のための人工標準蛋白作製2010

    • Author(s)
      岩元真、藤田佳子、垣野明美、柳田一樹、善本亮、沢村達也
    • Organizer
      第83回日本生化学会大会、第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
  • [Presentation] プロシアニジンは酸化LDL受容体LOX-1のアンタゴニストであり、ラット血管壁への脂質沈着を抑制する2010

    • Author(s)
      西塚太一、藤田佳子、佐藤優子、中野厚史、垣野明美、大嶋俊二、神田智正、善本亮、沢村達也
    • Organizer
      第20回日本循環薬理学会
    • Place of Presentation
      札幌
    • Year and Date
      2010-11-11
  • [Presentation] C-REACTIVE PROTEIN BINDS TO LOX-1 AND CAUSES VASCULAR DYSFUNCTION VIA COMPLEMENT ACTIVATION2010

    • Author(s)
      藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
    • Organizer
      International SHR Symposium
    • Place of Presentation
      モントリオール
    • Year and Date
      2010-09-25
  • [Presentation] LOX-1 is involved in the complement activation by endogenous C-reactive protein and myocardial reperfusion injury2010

    • Author(s)
      藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
    • Organizer
      15th World Congress on Heart Disease
    • Place of Presentation
      バンクーバー
    • Year and Date
      2010-07-25
  • [Presentation] The effect of LOX-1 and LOX-1 ligand containing ApoB on the incidence of coronary heart disease and stroke in an 11-year population-based cohort study : The Suita study2010

    • Author(s)
      Okamura, T., Inoue, N., Kokubo, Y., Fujita, Y., Sato, Y., Watanabe, M., Sawamura, T.
    • Organizer
      第42回日本動脈硬化学会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
  • [Presentation] Recognition of endogenous C-reactive protein by LOX-1 abrogates myocardial infarction2010

    • Author(s)
      藤田佳子、乙井一典、垣野明美、山口三郎、佐藤優子、善本亮、沢村達也
    • Organizer
      ISHR (World Congress of the International Society for Heart Research)
    • Place of Presentation
      京都
    • Year and Date
      2010-05-13
  • [Presentation] CRPはSR-Aを介してマクロファージに取り込まれる2010

    • Author(s)
      藤田佳子、垣野明美、佐藤優子、善本亮、沢村達也
    • Organizer
      第83回薬理学会年会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-03-16
  • [Presentation] HSP90は細胞膜受容体を介して血管新生を促進する2009

    • Author(s)
      佐藤優子、藤田佳子、垣野明美、小倉紗世子、岩元真、善本亮、沢村達也
    • Organizer
      第19回日本循環薬理学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
  • [Presentation] CRPによる心筋梗塞悪化へのLOX-1の関与2009

    • Author(s)
      藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      大宮
    • Year and Date
      2009-10-24
  • [Presentation] CRPはLOX-1依存性に補体系を活性化し、心筋梗塞を悪化させる2009

    • Author(s)
      藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、沢村達也
    • Organizer
      高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-04
  • [Presentation] 酸化LDL受容体LOX-1はCRPと協調して血管機能変化・心筋梗塞巣拡大を引き起こす2009

    • Author(s)
      藤田佳子、垣野明美、乙井一典、山口三郎、佐藤優子、小倉紗世子、岩元真、沢村達也
    • Organizer
      第7回メタボリックシンドローム研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-07-18
  • [Presentation] LOX-1 BINDS TO C-REACTIVE PROTEIN AND MEDIATES ITS EFFECTS ON CARDIOVASCULAR SYSTEM2009

    • Author(s)
      藤田佳子、垣野明美、乙井一典、西道教尚、山口三郎、松田治男、沢村達也
    • Organizer
      国際動脈硬化学会
    • Place of Presentation
      ボストン
    • Year and Date
      2009-06-17
  • [Remarks] ホームページ等なし

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Published: 2012-02-13   Modified: 2016-04-21  

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