2011 Fiscal Year Final Research Report
Role of TRB family in liver disease
| Project/Area Number |
21790263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAIJOU Eiko 東京大学, 分子細胞生物学研究所, 技術職 (60376647)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞医化学 |
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| Research Abstract |
TRB family member TRB1 was expressed in hepatoblast fraction inE14 fetal liver of mouse. Overexpression of TRB1 induced suppression of hepatocytedifferentiation marker TAT. In contrast, hepatocyte differentiation marker expression wasincreased in fetal liver of TRB1 deficient mouse. Luciferase assay revealed that TRB1inhibits C/EBPα transcriptional activity in a dose dependent manner.
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Research Products
(2 results)
