2010 Fiscal Year Final Research Report
The role of NMDA receptor/PSD-95/SPAL-1/Rap signaling in higher brain function
| Project/Area Number |
21790265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAWASAKI Yoshihiro The University of Tokyo, 分子細胞生物学研究所, 講師 (10376642)
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| Project Period (FY) |
2009 – 2010
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| Keywords | SPAL / PSD-95 / NMDA受容体 |
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| Research Abstract |
In this study, we carried out a series of electrophysiological recordings with a focus on CA1 and CA3 regions in hippocampal slices from SPAL-1 KO mice. Most of the electrophysiological properties of the CA1 were normal. However, we found mossy fiber LTP recorded in CA3 region was significantly impaired. Furthermore, we found that phospholylation of p42/44 MAPK is significantly reduced in the stratum lucidum of CA3. Our study may contribute to the elucidation of the novel mechanism of mossy fiber LTP.
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