CommonMechanismforCancerProgressionandStratificationofEpithelia

2012 Fiscal Year Final Research Report

• Project/Area Number: 21790267
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kyoto University (2011-2012); Tokyo Medical and Dental University (2009-2010)
• Principal Investigator: MATSUI Takeshi 京都大学, 物質-細胞統合システム拠点, 特定拠点助教 (10452442)
• Project Period (FY): 2009 – 2012
• Keywords: 癌 / 細胞・組織 / 発生・分化

Research Abstract

Skin-specific secreted peptide, dermokine was expressed in colorectal and pancreatic cancer at the early-stageof carcinogenesis. Serum dermokine was potential biomarker in these cancers. In addition, activity of skin-specific protease, SASPase plays a key role in stratum corneum hydration through profilaggrin processing. SASPase was also expressed at the early-stage of carcinogenesis. These results suggested the potential link between cancer progression and stratification of epithelia.

Research Products

• [Journal Article] Dermokine Expression in Intraductal Papillary-Mucinous Neoplasm and Invasive Pancreatic Carcinoma (2012)
  • Author(s): Watanabe K, Oochiai T, Kikuchi S, Kumano T, Matsui T, Morimoto K, Yasukawa S, Nakamori S, Sasako M, Yanagisawa A, Otsuji E
  • Journal Title: Anticancer Res Volume: 32 Pages: 4405-4412
  • Peer Reviewed
• [Journal Article] Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma (2012)
  • Author(s): Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 3541-51
  • DOI: doi:10.1158/1078-0432.CCR-11-1007
  • Peer Reviewed
• [Journal Article] Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin (2012)
  • Author(s): Sandilands A,Brown SJ, Goh CS, Pohler E, Wilson NJ, Campbell LE, Miyamoto K, Kubo A, Irvine AD, Thawer-Esmail F, Munro CS, McLean WH, Kudoh J, Amagai M, Matsui T
  • Journal Title: J. Invest. Dermatol Volume: 132 Pages: 1507-10
  • DOI: doi:10.1038/jid.2011.479
  • Peer Reviewed
• [Journal Article] SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation (2012)
  • Author(s): Ono H, Imoto I, Kozaki K, Tsuda H, Matsui T, Kurasawa Y, Muramatsu T, Sugihara K, Inazawa J
  • Journal Title: Oncogene Volume: 31 Pages: 4923-4934
  • DOI: doi:10.1038/onc.2011.646
  • Peer Reviewed
• [Journal Article] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T, Miyamoto K, Kubo A, Kawasaki H, Ebihara T, Hata K, Tanahashi S, Ichinose S, Imoto I, Inazawa J, Kudoh J, Amagai M
  • Journal Title: EMBO Mol. Med Volume: 3 Pages: 320-333
  • DOI: doi: 10.1002/emmm.201100140
  • Peer Reviewed
• [Journal Article] YAP is a candidate oncogene for esophageal squamous cell carcinoma (2011)
  • Author(s): Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J
  • Journal Title: Carcinogenesis Volume: 32 Pages: 389-398
  • DOI: doi:10.1093/carcin/bgq254
  • Peer Reviewed
• [Journal Article] Dermokine as a novel biomarker for early-stage colorectal cancer (2010)
  • Author(s): Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E
  • Journal Title: J. Gastroenterol Volume: 45 Pages: 1201-11
  • DOI: doi:10.1007/s00535-010-0279-4
  • Peer Reviewed
• [Journal Article] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous-cell carcinoma (2010)
  • Author(s): Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J
  • Journal Title: Carcinogenesis Volume: 31 Pages: 1027-36
  • DOI: doi:10.1093/carcin/bgq053
  • Peer Reviewed
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution (2013)
  • Author(s): Matsui T
  • Organizer: RSC-iCeMS Joint International Symposium Cell-Material Integration and Biomaterial Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2013-03-18
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization and Evolution (2012)
  • Author(s): Matsui T
  • Organizer: 6th Annual Symposium on Nanobiotechnology, Cell-Material Integration and Biomaterial Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 20121108-09
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution. RSC-iCeMS Joint IaMammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and (2012)
  • Author(s): Matsui T
  • Organizer: The 35th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-12-13
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: The Montagna Symposium on the Biology of the Skin
  • Place of Presentation: Oregon, USA
  • Year and Date: 2012-10-12
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: Fujihara Seminar 2012: A new horizon of retroposon research
  • Place of Presentation: Kyoto
  • Year and Date: 2012-08-03
• [Presentation] Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Organizer: Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
  • Place of Presentation: Kobe
  • Year and Date: 2012-05-29
• [Presentation] Endogenous Retroviral-like Aspartic Protease, SASPase as a key modulator of skin moisturization (2012)
  • Author(s): Matsui T
  • Organizer: The 8th Okazaki Biology Conference: Speciation and Adaptation II - Environment and Epigenetics -
  • Place of Presentation: Okazaki
  • Year and Date: 2012-03-23
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. Heidelberg-Kyoto Joint Symposium (2011)
  • Author(s): Matsui T
  • Organizer: Crossing Boundaries: Stem Cells, Materials, and Mesoscopic Sciences
  • Place of Presentation: Heidelberg, Germany
  • Year and Date: 20110721-23
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T
  • Organizer: Epithelial Differentiation & Keratinization Gordon Research Conference
  • Place of Presentation: USA
  • Year and Date: 20110703-08
• [Presentation] Evolutionally integrated retroviral-like aspartic protease, SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (2011)
  • Author(s): Matsui T
  • Organizer: The 34th Annual Meeting of the Molecular Biology Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2011-12-13
• [Presentation] 表皮の顆粒層特異的に発現するプロテアーゼSASPaseによる、角質層水分量の制御機構 (2011)
  • Author(s): Matsui T
  • Organizer: The 61st Annual Meeting of Japanese Society of Allergology
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-11
• [Presentation] 皮膚表皮顆粒層特異的なレトロウイルス型アスパラギン酸プロテアーゼSASPaseは、ProfilaggrinからFilaggrinへの分解を制御し、角質層の水分量を調節する (2011)
  • Author(s): Matsui T
  • Organizer: The 84th Annual Meeting of the Japanese Biochemical Society
  • Place of Presentation: Kyoto
  • Year and Date: 2011-09-22
• [Presentation] 脊椎動物陸上進出の謎と皮膚の美容 (2011)
  • Author(s): Matsui T
  • Organizer: The 29th Annual Meeting of the Japanese Society of Aesthetic Dermatology
  • Place of Presentation: Yamaguchi
  • Year and Date: 2011-09-10
• [Presentation] 陸上脊椎動物において獲得された皮膚表皮顆粒層特異的なレトロウイルス型プロテアーゼSASPaseは、角質層の水分量を調節する (2011)
  • Author(s): Matsui T
  • Organizer: Annual Meeting for the Society of Evolutionary Studies
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-30
• [Presentation] Analysis and clinical application of dermokines, stratified epithelia-specific secreted proteins (2009)
  • Author(s): Matsui T
  • Organizer: Gordon research Conference-Epithelial Differentiation & Keratinization
  • Place of Presentation: Les Diabretes, Switzerland
  • Year and Date: 2009-06-24
• [Presentation] SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing (0)
  • Author(s): Matsui T
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Kyoto
  • Year and Date: 00001110
• [Book] Endogenous Retroviral-Like Aspartic Protease, SASPase as a Key Modulator of Skin Moisturization (2012)
  • Author(s): Matsui T
  • Total Pages: 179-192
  • Publisher: Treatment of Dry Skin Syndrome -The Art and Science of Moisturizers- Edited by Loden and Maibach, Springer, Part 2
• [Remarks]
  • URL: http://epithelial.evolution.jp/TakeshiMatsui/Japanese.html