2010 Fiscal Year Final Research Report
Involvement of oncogenes in the self-renewal of ES cells
| Project/Area Number |
21790268
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
AKAGI Tadayuki Kanazawa University, 医学系, 助教 (70532183)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 胚性幹細胞 / がん遺伝子 / がん幹細胞 |
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| Research Abstract |
Pluripotent mouse embryonic stem (ES) cells proliferate with an undifferentiated status (i.e. self-renewal) in the presence of leukemia inhibitory factor (LIF). Cancer cells are characterized as immature malignant cells with features of aggressive proliferation and metastasis to other tissues. Interestingly, stem cells and cancer cells share similar feature : Proliferation with an undifferentiated status. This finding indicates that oncogenes might be involved in self-renewal of ES cells. In the present study, I focused on oncogenes and investigated its roles and functions in ES cells.
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Research Products
(13 results)
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[Journal Article] Genomic profiling of adult acute lymphoblastic leukemia (ALL) by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric ALL.2010
Author(s)
Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP.
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Journal Title
Haematologica. 95
Pages: 1481-1488
Peer Reviewed
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[Journal Article] Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma.2009
Author(s)
Akagi T, Ito T, Kato M, Jin Z, Cheng Y, Kan T, Yamamoto G, Olaru A, Kawamata N, Boult J, Soukiasian HJ, Miller CW, Ogawa S, Meltzer SJ, Koeffler HP.
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Journal Title
Int J Cancer. 125
Pages: 2349-2359
Peer Reviewed
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