2010 Fiscal Year Final Research Report
Mechanism of secreting soluble insulin receptor in diabetes
Project/Area Number |
21790279
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
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Research Institution | The University of Tokushima |
Principal Investigator |
NAGAYA Hisao The University of Tokushima, 疾患酵素学研究センター, 助教 (60464343)
|
Project Period (FY) |
2009 – 2010
|
Keywords | 生体分子医学 / インスリンシグナル伝達 |
Research Abstract |
Insulin is one of the key proteins in diabetes. Insulin receptor is also important in diabetes. We found that soluble insulin receptor in serum is increased in diabetes. In this study, we reconstructed that insulin receptor is released using human cultured cell line and human insulin receptor overexpression cell line. This system will be contributed the uncovering diabetes mechanism.
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[Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる2009
Author(s)
湯浅智之, 小畑利之, 横田一郎, 岡本英治, 長屋寿雄, 橋田誠一, 前川聡, 柏木厚典, 松本満, 松本俊夫, 岸和弘, 蛯名洋介
Organizer
1型糖尿病研究会, 第7回1型糖尿病研究会
Place of Presentation
日光
Year and Date
20091100
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[Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker, The Japanese Cancer Association2009
Author(s)
Yuasa Tomoyuki, Yano Seiji, Nishioka Yasuhiko, Kubo Yoshiaki, Takahashi Masayuki, Nakatsuji Hiroyoshi, Nagaya Hisao, Kanayama Hiro-omi, Arase Seiji, Sone Saburo, Ebina Yousuke
Organizer
第68回日本癌学会学術総会記事, pp.450-450
Place of Presentation
Yokohama
Year and Date
20091000
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[Presentation] 可溶化インスリン受容体細胞外ドメイン(sIR)は癌患者血清中で増加している2009
Author(s)
湯浅智之, 小畑利之, 矢野聖二, 岡本英治, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
Organizer
第29回日本分子腫瘍マーカー研究会事務局, 第29 回日本分子腫瘍マーカー研究会プログラム, pp.70-71
Place of Presentation
横浜
Year and Date
20090900
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[Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2009
Author(s)
Yuasa Tomoyuki, Obata Toshiyuki, Yokota Ichiro, Okamoto Eiji, Kanezaki Yoshiko, Maegawa Hiroshi, Hirota Fumiko, Kishi Kazuhiro, Hashida Seiichi, Nagaya Hisao, Yuko Ogura, Kazuhiko Masuda, Matsumoto Mitsuru, Matsumoto Toshio, Kashiwagi Atsunori, Ebina Yousuke
Organizer
International Symposium on Diabetes -Kickoff of Hannover-Tokushima Research Communiation
Year and Date
20090300