2010 Fiscal Year Final Research Report
Characterization of a novel centrosome-localized protein
| Project/Area Number |
21790287
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
UMEDA Kazuaki Kumamoto University, 大学院・生命科学研究部, 講師 (80444876)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | FCHO2 / エンドサイトーシス |
|---|
| Research Abstract |
We have previously identified the endocytic protein SGIP1α. This molecule through its MP domain binds to phospholipids and deforms the plasma membrane and liposomes into narrow tubes. We have found SGIP1α-related proteins FCHO1 and FCHO2, which have EFC/F-BAR domains substitute for MP domain. We examined the function of FCHO2, including tissue distribution, cellular localization and biochemical properties. Our results indicate that FCHO2 is involved in clathrin-dependent endocytosis.
|
