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2010 Fiscal Year Final Research Report

Dysfunction of the chromatin remodeling SWI/SNF complex effects the gastric tumorigenesis and gastrointestinal differentiation.

Research Project

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Project/Area Number 21790306
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMICHI Nobutake  The University of Tokyo, 医学部附属病院, 助教 (30463897)

Project Period (FY) 2009 – 2010
Keywords胃癌 / 腸上皮化生 / エピジェネティクス / 消化管分化 / Cdx2 / SWI / SNF複合体 / Brm / miRNA
Research Abstract

The histologic type of gastric cancer is quite important for prediction of the patient's prognosis, evaluating the risk of invasion and/or metastasis, selection of the anti-tumor therapy, etc. Based on our recent study showing a correlation between Brm-deficiency and undifferentiated status of gastric cancer, we analyzed the expression of villin gene and found that Brm-type chromatin-remodeling SWI/SNF complex cooperatively regulates villin expression with Cdx2. Brm-deficiency in gastric canceration should influence expression of many gastrointestinal genes regulated by Cdx2, a transcription factor essential for intestinal development and homeostasis. It is strongly suggested that the correlation between Brm-deficiency and various histologic features of gastric cancer is based on the interaction with Cdx2 and the Brm-type SWI/SNF complex.

  • Research Products

    (9 results)

All 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Long-term outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms.2010

    • Author(s)
      Niimi K, Fujishiro M, Kodashima S, Goto O, Ono S, Hirano K, Minatsuki C, Yamamichi N, Koike K.
    • Journal Title

      Endoscopy. 42

      Pages: 723-729

    • Peer Reviewed
  • [Journal Article] A second-look endoscopy after endoscopic submucosal dissection for gastric epithelial neoplasm may be unnecessary : a retrospective analysis of postendoscopic submucosal dissection bleeding.2010

    • Author(s)
      Goto O, Fujishiro M, Kodashima S, Ono S, Niimi K, Hirano K, Yamamichi N, Koike K.
    • Journal Title

      Gastrointest Endosc. 71

      Pages: 241-248

    • Peer Reviewed
  • [Journal Article] Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms.2009

    • Author(s)
      Ono S, Fujishiro M, Niimi K, Goto O, Kodashima S, Yamamichi N, Omata M.
    • Journal Title

      Gastrointest Endosc. 70

      Pages: 860-866

    • Peer Reviewed
  • [Journal Article] Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts.2009

    • Author(s)
      Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H.
    • Journal Title

      J Virol. 83

      Pages: 11569-11580

    • Peer Reviewed
  • [Journal Article] Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development.2009

    • Author(s)
      Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Clin Cancer Res. 15

      Pages: 4009-4016

    • Peer Reviewed
  • [Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.2009

    • Author(s)
      Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
    • Journal Title

      Exp Cell Res. 315

      Pages: 1779-1789

    • Peer Reviewed
  • [Presentation] Cdx2とSWI/SNF複合体による腸上皮化生進展の分子機構-villin遺伝子に着目して2010

    • Organizer
      第9回消化器病フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-11-20
  • [Presentation] クロマチン構造変換因子SWI/SNF複合体の胃癌における発現異常 触媒サブユニットBrmの発現欠失、組織型・分化マーカーとの関係2009

    • Organizer
      JDDW 2009
    • Place of Presentation
      京都
    • Year and Date
      2009-10-13
  • [Remarks] 特になし

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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